Welcome To EONS v1!
EONS v1 is the perfect tool to study the basic interactions between synaptic elements in a friendly manner. There are no complicated equations to write: all the models are predefined! This version is a great tool for first time users and students interested in learning about synapses, as well as for studying geometry and distribution hypotheses in a 2D rectangular geometry.
From a computational standpoint, EONS is currently a windows only application
Structure of EONS v1.*
EONS consists in a graphical modeling platform in which elements that comprise a single glutamatergic synapse (both pre- and post-synaptically) as well as the underlying synaptic geometry can be modified.
|This animation describes the main mechanisms involved during glutamatergic synaptic tranmission occuring after initial presynaptic depolarization. Click on 'Play' to start the video.|
- Calcium channels (N, L, T types)
- Localized calcium buffers
- Diffuse calcium buffers
- Calcium diffusion modeling
- Calcium pumps
- vesicular kinetics
Synaptic cleftIn the synaptic cleft, a uniform diffusion of neurotransmitter is modeled (we focus our attention to the area close the the release site).
- AMPA receptors
- NMDA receptors
- Metabotropic glutamate receptors
- Endoplasmic Reticulum (ER)
- ER calcium ATPase
- ER IP3 receptors
- Simulated excitatory postsynaptic potential
- Slow and medium potassium channels
- Calcium channels
- Sodium/calcium exchanger
- Long Term Potentiation (LTP)